DSIP 10mg

DSIP is the nonapeptide Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, and it has one of the more unusual origin stories in peptide research.

In 1977 the Schoenenberger and Monnier group in Basel induced a slow-wave EEG state in rabbits using low-frequency electrical stimulation of thalamic structures. They then collected cerebral venous blood from those animals, dialysed it, and purified a peptide fraction from the dialysate. Administered to recipient rabbits, that fraction was reported to reproduce the same EEG pattern. The peptide was named for the effect that led to its isolation: delta sleep-inducing peptide.

Nearly five decades later, the primary receptor for DSIP has still not been identified. The gap limits what research with this compound can conclude. Studies measure downstream observations rather than receptor occupancy, and mechanism remains open.

Published work covers EEG architecture and slow-wave activity, corticotropin and somatotropin release, stress-response models, and thermoregulation. Findings across the literature are mixed, which is consistent with a compound whose target is unknown.

Epithalon is the other compound here with a circadian connection, though it reaches the question from the pineal side rather than from EEG.

Supplied as a lyophilised powder at ≥99% purity by HPLC, with batch LC-MS identity confirmation and a certificate of analysis. Reconstitute with bacteriostatic water. Store the sealed vial at -20°C and keep reconstituted solution at 2-8°C, protected from light.

For in-vitro laboratory research only. Not for human or veterinary use.