Kisspeptin-10 10mg

Kisspeptin-10 is a decapeptide, Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2, the C-terminal fragment of the 54-residue parent kisspeptin. The short form retains receptor activity, which is why research uses it in place of the full-length peptide.

Its receptor, KISS1R, was known as GPR54 before its ligand was found: a 398-residue G-protein-coupled receptor sitting on hypothalamic neurons. Binding activates Gαq/11, then phospholipase C, then intracellular calcium mobilisation, and the result is GnRH release into the portal circulation.

Human genetics established how much this pathway carries. Loss-of-function mutations in KISS1R cause hypogonadotropic hypogonadism, transmitted recessively, and account for an estimated 2 to 4 percent of normosmic idiopathic cases. Break this receptor and the reproductive axis does not start, which is the finding that moved kisspeptin from an orphan ligand to the recognised gatekeeper of GnRH secretion.

Published work has measured GnRH and gonadotropin release, pulse generation in the hypothalamus, and the pathway’s response to metabolic and stress input.

This compound acts at the top of the reproductive axis. HCG acts at the bottom, on the gonadal receptor itself. The two are complementary tools for locating where along that axis a signal is being lost.

Supplied as a lyophilised powder at ≥99% purity by HPLC, with batch LC-MS identity confirmation and a certificate of analysis. Reconstitute with bacteriostatic water. Store the sealed vial at -20°C and keep reconstituted solution at 2-8°C, protected from light.

For in-vitro laboratory research only. Not for human or veterinary use.